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We are conducting a clinical trial for a new investigational drug, for Metabolic Dysfunction-Associated Steatohepatitis (MASH).
This trial will study whether the investigational drug will reduce liver fat, liver injury, and liver scarring in people with MASH. We are recruiting male and female participants who have MASH and are aged 18-65 years.
By taking part, you could make a difference for people living with MASH.
What taking part in this study involves
This clinical trial is divided into two parts. We are recruiting for Part B.
- You will need to attend 3 screening appointments so we can check if you are suitable to take part in the trial. At these appointments, we will perform assessments including taking blood, checking your heart, carrying out a physical examination, conducting scans of your liver, and possible biopsy
- If you’re eligible, you will receive 2 doses of the study treatment (either the trial drug or placebo) during the trial, 12 weeks apart. The study treatment is given as an injection under the skin
- The study involves in-house stays of 4 days / 3 nights in our London Bridge unit
- You will then need to attend 5 follow-up visits over a period of 9 months. That means the trial will take approximately 58 weeks from your screening visit through to your final visit
Who can take part?
You may be eligible for this clinical trial if:
- You are aged between 18-65 years
- You have been diagnosed with MASH
- At your first screening visit, your BMI is between 30-40kg/m2
- You do not have a history of significant multiple and/or severe allergies
- You are not pregnant or breastfeeding
Please note there are additional study criteria. A full list will be given to you by a member of our recruitment team if you are interested.
You could receive up to £4,150
You will receive £4,150 on completion of the clinical trial, provided you comply fully with the trial requirements. This amount will be adjusted pro-rata if we invite you to attend extra visits.
Trial dates
This trial has multiple possible intake dates for the 4 days/3 nights in-house stays. When you are enrolled on the trial, you will choose your preferred dates from the list below:
- 3rd – 6th February 2026 & 28th April – 1st May 2026
- 17th – 20th February 2026 & 12th – 15th May 2026
- 8th – 11th March 2026 & 31st May – 3rd June 2026
- 23rd – 26th March 2026 & 15th – 18th June 2026
You will then also be required to attend follow-up sessions. Dates for follow up visits will be discussed with you by our team.
Dates are subject to change. Please call a recruitment team member on 020 7042 5802 to discuss study dates, or register to receive a call back.
Approval
The contents of this page have been approved by an ethics committee. Any response to this advertisement will be recorded. Your response will not place you under any obligation to participate in this study.
Ref: C24017_Mar-2025 (email_website_advert text)
