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Trial Summary
We are currently seeking adults, with or without metabolic dysfunction-associated steatotic liver disease (MASLD), also known as fatty liver disease.
This includes individuals diagnosed with conditions such as Type 1 or Type 2 diabetes, high blood pressure (hypertension), non-alcoholic steatohepatitis (NASH), heart failure, or familial hypercholesterolaemia (FH).
The purpose of this study is to collect information to support the development of improved methods for detecting fatty liver disease, which can affect up to 1 in 4 adults. Fatty liver disease can range from having no symptoms to causing liver inflammation, scarring or more serious health problems.
This study doesn’t involve a new investigational medicine and is considered low risk.
If you are interested in participating in this observational study:
- You will need to attend an in-person visit at our clinical research unit, where you will be given an overview of the study and asked to provide informed consent.
- Following this, you will undergo a series of assessments, including body measurements, vital signs, physical examination, electrocardiogram (ECG), blood tests, and a liver ultrasound.
- Additional assessments may be performed where clinically indicated.
Who can take part?
We will check your suitability for this screening visit using the following criteria:
- You are aged between 18 to 80 years inclusive.
- You are willing and able to provide written informed consent.
- You are willing and able to comply with all study procedures.
- For Part B: you have a known history of MASLD, confirmed by a GP diagnosis or documented FibroScan or liver ultrasound findings.
Payment
In recognition of the time involved in this medical check-up, you will receive £136 and reimbursement of reasonable travel expenses.
Dates
Following the completion of your registration form, a member of our recruitment team will contact you via phone and email to inform you about the available dates.
Approval
The contents of this page have been approved by an ethics committee. Any response to this advertisement will be recorded. Your response will not place you under any obligation to participate in the study.
Ref: C19030-May-2026
Question: What is fatty liver disease?
Answer: Fatty liver disease happens when too much fat builds up in the liver. It is common and is often linked to being overweight, diabetes, high cholesterol, or drinking too much alcohol. Many people do not notice symptoms at first, but over time it can sometimes cause liver damage if left untreated.
Question: What are the common symptoms of fatty liver disease?
Answer: Many people do not have any symptoms. Some people may experience: tiredness or low energy, pain or discomfort on the right side of the stomach area, feeling generally unwell or unexplained weight changes.
Question: Do I need a diagnosis to register?
Answer: Not necessarily. You may still be able to take part if you do not already have a diagnosis.
To be considered for the study, you must be aged 18 to 80 years, be willing to give written consent and be able to attend and complete study procedures.
For Part B only, you must already have a diagnosis or evidence of MASLD (fatty liver disease), such as a GP diagnosis, FibroScan, or liver ultrasound result.
Question: What happens after I register?
Answer: After you register, a member of the study team will review your information and contact you if you may be suitable for the study. You may then be invited to attend a screening visit, where the team will explain the study, answer your questions, and confirm whether you are eligible to take part.
Question: What will I receive if I take part?
Answer: You will complete a number of health checks, which may include: body measurements, blood pressure, pulse and temperature checks, a physical examination, an electrocardiogram (ECG), blood tests and a liver ultrasound. Additional tests may be carried out if needed.
You will receive £136 for completing the study, plus reimbursement of reasonable travel expenses.
Question: Is taking part voluntary?
Answer: Yes. Taking part in the study is completely voluntary. You are free to stop taking part at any time without giving a reason.
