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Clinical trial summary
We are conducting a clinical trial for an investigational drug that could be used to treat people with uncontrolled hypertension (uncontrolled high blood pressure despite taking multiple medications). During the study, we will observe:
- How your body processes the investigational drug
- How your body responds to the investigational drug
- What side effects the drug may have
- If it works to control high blood pressure
- How long it stays in your body
You will be paid for your time if you take part in this clinical trial and could help make a difference for people living with high blood pressure.
What taking part in this study involves
This clinical trial will last up to 14 months and includes:
- 1 screening appointment
- 1-2 short stays in our research clinic
- Up to 16 follow up visits
You will need to attend a screening appointment so we can check if you are suitable to take part in the trial. At this appointment, we will take blood samples, check your heart function and carry out a physical examination, among other assessments. If the results from your screening appointment show that you are suitable for the trial, you will be invited to take part.
Participation will involve a stay of 3 days / 2 nights in our clinical research unit. During your stay, you will receive a single dose of the investigational drug as an intravenous infusion (given into a vein through a small tube in your arm or hand). We will conduct a number of assessments to check how well you tolerate the investigational drug, to help us find out how your body processes and responds to the investigational drug, what side effects the drug may have, if it works to control high blood pressure and how long it stays in your body.
You will be required to return to the study unit for 11 follow-up visits over a 12-month period following your stay.
If you receive a second dose, you will return to the study unit for another 3 day visit, and 4 additional follow-up visits (totalling up to 16 visits)
The whole process will take up to 14 months from your screening visit through to your final visit.
Who can take part?
We will check your suitability for the clinical trial using the following criteria:
- You are male or female aged between 18 and 75 years (inclusive).
- You have a body mass index (BMI) less than or equal to 40 kg/m2.
- You must not participate if you have certain medical conditions that could make the study unsafe for you.
- You must not have participated in a clinical trial with an investigational drug within the last 30 days before dosing.
- You must not be pregnant or breastfeeding or planning to become pregnant.
- Female participants of childbearing potential: You must be on a highly effective method of contraception and willing to continue using this method for the duration of the trial and for at least 12 months after dosing/last dose.
- Male participants with female partners of childbearing potential: You must be willing to use an acceptable method of contraception such as a condom with a spermicide for the duration of the trial and for at least 12 months after dosing. In addition, your female partner of childbearing potential must also use a highly effective method of contraception.
A full list of do’s and don’ts will be given to you by a member of our recruitment team if you are interested.
Clinical trial payment
In recognition of the time involved in taking part in the trial, you will receive between £7,025-£10,225 on completion of the clinical trial, provided you comply fully with all the clinical trial requirements.
This amount is based on the anticipated clinical trial plan and will be adjusted pro-rata (i.e. same amount of money paid per unit of time), should we invite you to attend extra visits.
Approval
The contents of this page have been approved by an ethics committee. Any response to this advertisement will be recorded. Your response will not place you under any obligation to participate in this study.
Ref: C250868_Mar-2026
